https://ogma.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:42661 Wed 31 Aug 2022 13:44:21 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:51421 Wed 28 Feb 2024 15:25:16 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:34513 Wed 27 Apr 2022 14:49:53 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:29875 Wed 27 Apr 2022 14:49:21 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:39776 Wed 22 Jun 2022 12:26:08 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:40187 Wed 20 Jul 2022 14:17:50 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:48375 Wed 15 Mar 2023 13:47:42 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:4358 90% (p=.14), the duration of gametocyte carriage increased from 3 to 22 weeks (per 1000 person‐weeks) between 1998 and 2002 (p≺.001). The dhfr and dhps mutations associated with sulfadoxine‐pyrimethamine resistance were the most important drivers of the increased gametocytemia, although these mutations were not associated with increased pretreatment asexual parasite density or slower asexual parasite clearance times. The geometric mean gametocyte duration and area under the gametocyte density time curve (per 1000 person‐weeks) were 7.0 weeks and 60.8 gametocytes/μL per week, respectively, among patients with wild‐type parasites, compared with 45.4 weeks (p=.016) and 1212 gametocytes/μL per week (p=.014), respectively, among those with parasites containing 1–5 dhfr/dhps mutations. Conclusions: An increased duration and density of gametocyte carriage after sulfadoxine-pyrimethamine treatment was an early indicator of drug resistance. This increased gametocytemia among patients who have primary infections with drug‐resistant Plasmodium falciparum fuels the spread of resistance even before treatment failure rates increase significantly.]]> Wed 11 Apr 2018 13:43:20 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:14871 Wed 11 Apr 2018 10:34:19 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:54474 Tue 27 Feb 2024 14:35:23 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:55368 Tue 21 May 2024 09:42:55 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:37182 Acinetobacter baumannii has rapidly emerged as a major cause of gram-negative hospital infections worldwide. A. baumannii encodes for the transport protein AceI, which confers resistance to chlorhexidine, a widely used antiseptic. AceI is also the prototype for the recently discovered proteobacterial antimicrobial compound efflux (PACE) family of transport proteins that confer resistance to a range of antibiotics and antiseptics in many gram-negative bacteria, including pathogens. The gene encoding AceI is conserved in the core genome of A. baumannii, suggesting that it has an important primordial function. This is incongruous with the sole characterized substrate of AceI, chlorhexidine, an entirely synthetic biocide produced only during the last century. Here we investigated a potential primordial function of AceI and other members of the PACE family in the transport of naturally occurring polyamines. Polyamines are abundant in living cells, where they have physiologically important functions and play multifaceted roles in bacterial infection. Gene expression studies revealed that the aceI gene is induced in A. baumannii by the short-chain diamines cadaverine and putrescine. Membrane transport experiments conducted in whole cells of A. baumannii and Escherichia coli and also in proteoliposomes showed that AceI mediates the efflux of these short-chain diamines when energized by an electrochemical gradient. Assays conducted using 8 additional diverse PACE family proteins identified 3 that also catalyze cadaverine transport. Taken together, these results demonstrate that short-chain diamines are common substrates for the PACE family of transport proteins, adding to their broad significance as a novel family of efflux pumps.]]> Thu 27 Aug 2020 12:47:49 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:52222 Thu 05 Oct 2023 10:30:50 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:992 Sat 24 Mar 2018 08:29:50 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:1006 Sat 24 Mar 2018 08:29:45 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:1483 Sat 24 Mar 2018 08:28:12 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:14589 Sat 24 Mar 2018 08:20:46 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:12352 Sat 24 Mar 2018 08:18:31 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:20451 Sat 24 Mar 2018 08:06:58 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:20878 Sat 24 Mar 2018 07:57:56 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:26889 Sat 24 Mar 2018 07:41:40 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:36157 Mon 26 Oct 2020 12:11:15 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:49246 Mon 08 May 2023 10:28:15 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:49407 Fri 12 May 2023 14:55:16 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:47881 Fri 03 Feb 2023 15:52:53 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:42774 Fri 02 Sep 2022 11:00:23 AEST ]]>